Per- and polyfluoroalkyl substances (PFAS) are a class of emerging and strictly anthropogenic pollutants that pose significant risks to human health and the aquatic environment. These chemicals are widely recognized for their extensive use in various industrial and consumer products, such as firefighting foams, non-stick cookware, water-resistant fabrics, and food packaging. Due to their widespread application, PFAS are now ubiquitous in the environment. Exposure to PFAS has been associated with serious health effects, including high cholesterol, thyroid disease, kidney and testicular cancers, and pregnancy-induced hypertension. Regulatory agencies, such as the U.S. Environmental Protection Agency (EPA), have responded by implementing measures such as setting Maximum Contaminant Levels (MCLs) and listing certain PFAS as hazardous substances under the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) to mitigate exposure risks and enhance accountability. PFAS's environmental persistence is a direct consequence of their unique chemical structure, particularly the strong carbon-fluorine bonds. These bonds confer remarkable stability, rendering PFAS resistant to conventional thermal, chemical, and biological degradation. As a result, these substances are often referred to as "forever chemicals." This presentation critically reviews emerging technologies currently being investigated for PFAS destruction. The primary focus is on innovative, high-efficiency techniques that hold promise for future full-scale implementation. Among the technologies reviewed are electrochemical oxidation, photocatalytic oxidation, advanced chemical oxidation/reduction methods, plasma treatment, sonolysis, supercritical water oxidation, and biological treatment. Each of these technologies is systematically analyzed based on recent laboratory and pilot-scale studies for their treatment efficacy, scalability, and environmental feasibility. In addition, their capital and operational costs are explored to assess economic viability at full scale. Electrochemical oxidation and photocatalytic oxidation have demonstrated significant potential in achieving substantial PFAS degradation. These methods generate reactive radicals that effectively target and break the stable carbon-fluorine bonds. Similarly, advanced chemical oxidation/reduction technologies utilize strong oxidants under controlled conditions to achieve PFAS mineralization. Non-thermal technologies such as low-temperature plasma treatment provide energy-efficient pathways for PFAS degradation, offering scalable solutions that do not require extreme operating conditions. Sonolysis, which employs ultrasonic waves to degrade PFAS through bubble formation and subsequent cavitation, represents another promising approach. Additionally, supercritical water oxidation achieves near-complete PFAS mineralization by subjecting them to extreme temperature and pressure in aqueous environments. Biological treatment, while currently limited in its efficacy for PFAS destruction, is an area of active research. This presentation provides a comprehensive comparative assessment of these technologies, evaluating their degradation efficiencies, full-scale operational feasibility, and environmental implications. The findings underscore the importance of adopting multi-technique and treatment-train approaches to effectively address PFAS contamination in diverse environmental settings. By combining the advantages of various technologies, the limitations of individual methods can be mitigated, resulting in more robust and sustainable treatment solutions. This work contributes to ongoing efforts in environmental engineering, highlighting the urgent need for advanced and effective PFAS destruction technologies to mitigate the profound environmental and human health risks associated with these persistent pollutants.